GLUCORYL-M1

Introduction About GLUCORYL M 1MG TABLET GLUCORYL M 1MG TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. It is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. Glimepiride lowers blood sugar by causing the pancreas to produce more insulin and helps the body to use insulin efficiently. Metformin reduces the total amount of sugar released into the blood by the liver. Along management with GLUCORYL M 1MG TABLET follow regular exercise and diet plan as advised by your doctor to achieve better results. Before taking GLUCORYL M 1MG TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding. It is not suitable for use in children and adolescents under 18 years of age. Avoid consumption of alcohol during management with GLUCORYL M 1MG TABLET as it may increase or decrease the blood sugar lowering action of GLUCORYL M 1MG TABLET and increases the risk of lactic acidosis. The most common side effects of taking GLUCORYL M 1MG TABLET are taste disturbance, diarrhea or stomach ache. Contact your doctor if any of the symptoms worsen. Uses Of GLUCORYL M 1MG TABLET Used to manage type 2 diabetes mellitus (when diet, exercise and the single agent does not result in adequate glycemic control) How GLUCORYL M 1MG TABLET Works GLUCORYL M 1MG TABLET controls blood glucose levels, where Glimepiride works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestine, and increasing the body's sensitivity to insulin. How to use GLUCORYL M 1MG TABLET Take GLUCORYL M 1MG TABLET as advised by your physician Swallow GLUCORYL M 1MG TABLET with a glass of water. Do not crush or chew the medicine Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition Do not stop taking GLUCORYL M 1MG TABLET without informing your doctor.   Side Effects Of GLUCORYL M 1MG TABLET Common side effects of GLUCORYL M 1MG TABLET: taste disturbance diarrhea stomach pain loss of appetite Stop taking GLUCORYL M 1MG TABLET and contact your doctor immediately if you experience any of the following side effects: lactic acidosis inflammation of the liver which may result in jaundice (yellowing of skin or eyes) severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock) severe low blood sugar levels Warning & Precautions Pregnancy Contraindicated GLUCORYL M 1MG TABLET should not be taken during pregnancy. Consult your doctor before taking GLUCORYL M 1MG TABLET if you are planning to become pregnant. Breastfeeding Contraindicated GLUCORYL M 1MG TABLET should not be taken during breastfeeding as it may pass through breast milk. Driving and Using Machines Use with Caution Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels. Alcohol Consult your doctor Avoid consumption of alcohol during management with GLUCORYL M 1MG TABLET as it may increase or decrease the blood sugar lowering action of GLUCORYL M 1MG TABLET and increases the risk of lactic acidosis. Kidney Consult your doctor GLUCORYL M 1MG TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. Liver Consult your doctor GLUCORYL M 1MG TABLET is not recommended if you have severe liver disease and it should be used with caution in patients with liver disease and your dose will be adjusted if needed depending upon liver function. Allergy Contraindicated Do not take GLUCORYL M 1MG TABLET if you are allergic (hypersensitive) to Glimepiride or Metformin or other sulfonylureas (such as glipizide, glibenclamide) or sulfonamides (such as sulfamethoxazole). Heart Disease Contraindicated GLUCORYL M 1MG TABLET is not recommended for use in patients with acute heart problems or recently had a heart attack or have severe circulatory problems or breathing difficulties (signs of heart failure). Use In Pediatrics Contraindicated GLUCORYL M 1MG TABLET is not recommended for use in children and adolescents (under 18 years of age). Use In Geriatrics Consult your doctor GLUCORYL M 1MG TABLET is not recommended for use in elderly patients (aged 75 years or above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during management with GLUCORYL M 1MG TABLET.   Others GLUCORYL M 1MG TABLET is not recommended for use, if you have: type 1 diabetes mellitus diabetic ketoacidosis uncontrolled diabetes or ketoacidosis dehydration severe infection Before taking GLUCORYL M 1MG TABLET inform your doctor if you: are recovering from injury, operation, infections with fever, or from other forms of stress have glucose-6-phosphate dehydrogenase (G6PD) deficiency have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders) Interactions A. Drug-Drug interactions: Before taking GLUCORYL M 1MG TABLET inform to your doctor,  if you are taking any of these medicines: Sulphonylureas (Ex. glibenclamide, insulin) Anabolics Anticoagulants (Ex. Warfarin)   Anticonvulsants (Ex. Fenfluramine, Phenytoin) NSAIDs (Ex. Phenylbutazone, azopropazone, oxyphenbutazone) Class 1a anti-arrhythmic agent (Ex. Disopyramide) Fibrates (Ex. fenofibrate, nicotinic acid, colesevelam) Angiotensin-converting enzyme (Ex. captopril, lisinopril) Diuretics (Ex. furosemide, chlorthalidone, hydrochlorothiazide or diazoxide) Monoamine oxidase inhibitors (Ex. isocarboxazid, selegiline and chlorpromazine) Antigout agents (Ex. Allopurinol, probenecid, sulfinpyrazone) Alkylating agents (Ex. Cyclophosphamide, ifosfamide, trofosfamide) Tetracyclines (Ex. minocycline, doxycycline, chloramphenicol, fluconazole, miconazole Quinolones (Ex. moxifloxacin, ciprofloxacin, clarithromycin, rifampicin Tritoqualine, glucocorticoids (Ex. beclomethasone, hydrocortisone) Hemorrheologic agents (Ex. Pentoxifylline) Sulfonamides (Ex. sulfamethoxazole) Androstane class (Ex. testosterone) Natural or synthetic (Ex. oestrogens, progestogens) Sympatholytics (Ex. clonidine, methyldopa) Hormones (Ex. Levothyroxine)   Adrenaline and sympathomimetics (Ex. phenylephrine, norepinephrine) Laxatives (Ex. bisacodyl) Antidiabetics (Ex. Glucagon) Barbiturates (Ex. pentobarbital, amobarbital) Carbonic anhydrase inhibitors (Ex. Acetazolamide) Overdosage: If you or anyone else takes too much of GLUCORYL M 1MG TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of GLUCORYL M 1MG TABLET includes risk of low blood sugar levels. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat, and difficulty in breathing.